Enantiodivergent synthesis of both enantiomeric forms of substituted paraconic acids starting from N-mannitol as a chiral pool

Article abstract of DOI:10.1016/S0040-4039(99)00855-2

Acetamide-acetal Claisen rearrangement of the C₂-symmetric enediol easily derived from D-mannitol provided a chiral C8-building block, which was demonstrated to be versatile for divergent synthesis of both enantiomeric forms of substituted para