Efficient stereoselective preparation of protected isodityrosines

Article abstract of DOI:10.1016/S0040-4020(99)00576-1

A method for stereoselective preparation of isodityrosines with identical and orthogonal protecting groups is reported. The isodityrosines holding identical protecting groups were prepared from isovaniline in a three step procedure, in 50-64% yield (> 98% ee, 84-96% de). Isodityrosine holding four orthogonal groups was prepared in four steps from isovaniline in 20% total yield (> 98% ee, 87% de).