Isomeric Monomethyl Ether Derivatives of (RS)-9,10-Dihydroxyaporphine ("Isoapomorphine") as Possible Products of Metabolism by Catechol-O-methyltransferase

Article abstract of DOI:10.1021/jm00107a030

The isomeric monomethyl ether derivatives of (RS)-9,10-dihydroxyaporphine ("isoapomorphine") were synthesized unequivocally as possible metabolites in catechol-O-methyltransferase (COMT) mediated O-methylation reactions.In vitro incubation studies revealed that isoapomorphine is not a substrate for the COMT using experimental conditions under which apomorphine (10,11-dihydroxyaporphine) is converted in high yield into its 10-methyl ether, apocodeine.The in vivo dopaminergic inactivity of isoapomorphine (as compared with that of apomorphine) seems to be due to factors other than metabolic inactivation by COMT.