The design of (-)-(S)-2-nitrooxyethyl 1,4-dihydro-2,6-dimethyl-3-nitro-4-(2-trifluoromethylphenyl)pyridine-5-carboxyla te: A cardioselective positive inotropic derivative of Bay K 8644

DOI: 10.1016/S0960-894X(99)00445-X

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2613 - 2614 (1999)

Update date:2022-07-30

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Authors:

Shan, Rudong

Knaus, Edward E.

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Article abstract of DOI:10.1016/S0960-894X(99)00445-X

The title compound, (-)-(S)-9, is a novel cardioselective calcium channel modulator that exhibits a calcium channel agonist effect on heart, a weak calcium channel antagonist effect on smooth muscle, and releases nitric oxide in vitro. (-)-(S)-9 is a usef

Full text of DOI:10.1016/S0960-894X(99)00445-X

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