Evaluation of oligonucleotides containing two novel 2'-O-methyl modified nucleotide monomers: A 3'-C-allyl and a 2'-O,3'-C-linked bicyclic derivative

Article abstract of DOI:10.1080/07328319908044861

The two ribo-configured nucleosides 1-(3-C-allyl-2-O-methyl-β-D- ribopentofuranosyl)thymine 3 and (1S,5R,6R,8R)-5-hydroxy-6-(hydroxymethyl)-1- methoxy-8-(thymin-1-yl)-2,7-dioxabicyclo[3.3.0]octane 6 have been transformed into their corresponding phosphora

Full text of DOI:10.1080/07328319908044861

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Nucleosides and Nucleotides
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Evaluation of Oligonucleotides
Containing Two Novel 2′-O-Methyl
Modified Nucleotide Monomers: A 3′-
C-Allyl and a 2′-O-3′-C-Linked Bicyclic
Derivative
Henrik M. Pfundheller a , Alexei A. Koshkin b d , Carl Erik Olsen c &
Jesper Wengel b
a Department of Chemistry , University of Southern Denmark,
Odense University , DK-5230, Odense M, Denmark
b Center for Synthetic Bioorganic Chemistry, Department of
Chemistry, Chemical Laboratory II , University of Copenhagen ,
Universitetsparken 5, DK-2100, Copenhagen, Denmark
c Department of Chemistry , The Royal Veterinary and Agricultural
University , DK-1871, Frederiksberg C, Denmark
d Exiqon A/S , Bygstubben 9, DK-2950, Vedbék, Denmark
Published online: 04 Oct 2006.
To cite this article: Henrik M. Pfundheller , Alexei A. Koshkin , Carl Erik Olsen & Jesper Wengel (1999)
Evaluation of Oligonucleotides Containing Two Novel 2′-O-Methyl Modified Nucleotide Monomers: A
3′-C-Allyl and a 2′-O-3′-C-Linked Bicyclic Derivative, Nucleosides and Nucleotides, 18:9, 2017-2030,
DOI: 10.1080/07328319908044861
To link to this article: http://dx.doi.org/10.1080/07328319908044861
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