Synthetic approaches to condensed aromatic analogues from etoposide. Synthesis of A-ring pyridazine picroetoposide

Article abstract of DOI:10.1016/S0040-4020(99)00756-5

The studies feature the transformation of etoposide 1 into the pivotal intermediate (+)-19 for the elaboration of pyridazine-fused aromatic systems via a Stille cross-coupling. The synthesis of A-ring pyridazine picroetoposide (+)-21 has been achieved in