An efficient stereoselective synthesis of methyl (S)-3-amino-3-(3-pyridyl)propanoate

DOI: 10.1016/S0040-4039(99)01634-2

Source and publish data:

Tetrahedron Letters p. 7721 - 7725 (1999)

Update date:2022-08-05

Topics:

Authors:

Zhong, H. Marlon

Cohen, Judith H.

Abdel-Magid, Ahmed F.

Kenney, Birdella D.

Maryanoff, Cynthia A.

Shah, Rekha D.

Villani Jr., Frank J.

Zhang, Fan

Zhang, Xini

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Article abstract of DOI:10.1016/S0040-4039(99)01634-2

Methyl (S)-3-amino-3-(3-pyridyl)propanoate (2) is a key starting material in the synthesis of RWJ-53308 (1), an orally active antagonist of the platelet fibrinogen receptor (GP IIb/IIIa antagonist). Herein, we describe an efficient stereoselective synthes

Full text of DOI:10.1016/S0040-4039(99)01634-2

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