Design, synthesis and testing of amino-bicycloaryl based orally bioavailable thrombin inhibitors

DOI: 10.1016/S0960-894X(99)00483-7

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2837 - 2842 (1999)

Update date:2022-08-05

Topics:

Authors:

Rewinkel

Lucas Lucas

Smit Smit

Noach Noach

Van Dinther

Rood Rood

Jenneboer

Van Boeckel

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(99)00483-7

Replacement of the highly basic benzamidine moiety with moderate basic amino-bicycloaryl moieties in a series of thrombin inhibitors related to NAPAMP provided potent enzyme inhibition and significant improvements in membrane transport and oral bioavailability.

Full text of DOI:10.1016/S0960-894X(99)00483-7

Products guided by the article

Product name:[1-(4-amino-furo[3,2-c]pyridin-2-ylmethyl)-2-(4-methyl-piperidin-1-yl)-2-oxo-ethyl]-carbamic acid tert-butyl ester

Cas No:252971-51-0

R&D Labs maybe for 252971-51-0

Jiangsu Hualun Chemical Industry Co., Ltd

website:http://www.hualunchem.com

Contact:+86-0514-86464168 86507985

Address:39# Middle Renmin Road, Dinghuo Town
Shanghai KFSL Pharmaceutical Technology Co.,Ltd.

Contact:+86-21-39971718

Address:859 jiadingchengliu shanghai
Xi'an HO-SHINE Bio-Technology Co., Ltd

Contact:+86 (29) 8248-5435/18292020086

Address:No.6 Shiyuan Road Xian City Shaanxi Province, 710048 China
Jiande City Silibase Silicone New Material Manufacture Co., Ltd.

Contact:15967177856

Address:Genglou Industrial Development Area
A-Chem Technologies Co.,Ltd.

Contact:+86-512-69561895

Address:No.111, Building A4, 218 Xinghu Street, Suzhou Industrial Park, P. R. China

Relevant to this article

Reactivity of cationic organoaluminum aminotroponiminate compounds with unsaturated substrates. Formation of dinuclear dicationic aluminum complexes [20]

Doi:10.1021/ja992599c
(1999)
Calyculin synthetic studies. 2. Stereocontrolled assembly of the C(9)-C(13) dithiane and C(26)-C(37) oxazole intermediates

Doi:10.1016/S0040-4039(00)93480-4
(1991)
Imine-enamine tautomeric equilibrium of palladium imidoyl complexes

Doi:10.1021/om9905557
(1999)
Design, synthesis, and anti-inflammatory activity both in vitro and in vivo of new betulinic acid analogues having an enone functionality in ring A

Doi:10.1016/j.bmcl.2006.09.012
(2006)
The asymmetric synthesis of phosphorus- and sulfur-containing tricarbonyl(η⁶-arene)chromium complexes using the chiral base approach

Doi:10.1039/a905610f
(1999)
Sulfonamide molecular crystals: Thermodynamic and structural aspects

Doi:10.1021/cg1012389
(2011)

Article Doi