Bioorganic and Medicinal Chemistry Letters p. 3229 - 3233 (2002)
Update date:2022-08-04
Topics:
Sutton, James C.
Bolton, Scott A.
Hartl, Karen S.
Huang, Ming-Hsing
Jacobs, Glenn
Meng, Wei
Ogletree, Martin L.
Pi, Zulan
Schumacher, William A.
Seiler, Steven M.
Slusarchyk, William A.
Treuner, Uwe
Zahler, Robert
Zhao, Guohua
Bisacchi, Gregory S.
A series of N1-activated C4-carboxy azetidinones was prepared and tested as inhibitors of human tryptase. The key stereochemical and functional features required for potency, serine protease specificity and aqueous stability were determined. From these studies compound 2, BMS-262084, was identified as a potent and selective tryptase inhibitor which, when dosed intratracheally in ovalbumin-sensitized guinea pigs, reduced allergen-induced bronchoconstriction and inflammatory cell infiltration into the lung.
View MoreTaizhou Chemedir Biopharm-tech Co., Ltd
Contact:+86 523 86200218
Address:G09, No. 1 Avenue China Medical City, Taizhou,Jiangsu, China
JIANGXI ZHANGFENG CHEMICAL CO., LTD.
Contact:+86-0799-3413066
Address:Xiyuan village, Xiabu Town, Xiangdong District
Anyang Double Circle Auxiliary CO.,LTD
Contact:0086-134 6082 4403
Address:dongfeng road, anyang city, henan province,china
SPRING CHEMICAL INDUSTRY CO.,LTD
Contact:86-187-66672125
Address:linchi industry park.zouping
Contact:+ 86 512 52491118
Address:1 Fuyu Road, Haiyu TownChangshu, Jiangsu, China
Doi:10.1107/S0108270199009919
(1999)Doi:10.1039/a904369a
(1999)Doi:10.1016/S0040-4039(99)01763-3
(1999)Doi:10.1016/S0957-4166(99)00422-X
(1999)Doi:10.1055/s-1981-29608
(1981)Doi:10.1081/SCC-120018685
(2003)