Bioorganic and Medicinal Chemistry Letters p. 3047 - 3052 (1999)
Update date:2022-08-04
Topics:
Boge, Thomas C.
Wu, Zhi-Jun
Himes, Richard H.
Vander Velde, David G.
Georg, Gunda I.
Conformationally restricted macrocyclic analogues of paclitaxel were prepared, by connecting the 3'-phenyl group the 2-benzoate moiety with two-atom tethers to mimic the 'hydrophobic collapse' paclitaxel conformation. The analogues did not show activity in a tubulin assembly assay.
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