Conformationally restricted paclitaxel analogues: Macrocyclic mimics of the 'hydrophobic collapse' conformation

DOI: 10.1016/S0960-894X(99)00522-3

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 3047 - 3052 (1999)

Update date:2022-08-04

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Authors:

Boge, Thomas C.

Wu, Zhi-Jun

Himes, Richard H.

Vander Velde, David G.

Georg, Gunda I.

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Article abstract of DOI:10.1016/S0960-894X(99)00522-3

Conformationally restricted macrocyclic analogues of paclitaxel were prepared, by connecting the 3'-phenyl group the 2-benzoate moiety with two-atom tethers to mimic the 'hydrophobic collapse' paclitaxel conformation. The analogues did not show activity in a tubulin assembly assay.

Full text of DOI:10.1016/S0960-894X(99)00522-3

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