Synthesis p. 258 - 260 (1994)
Update date:2022-08-04
Topics:
Ayoubi
Texier-Boullet
Hamelin
Condensation of carbonyl derivatives 2 with active methylene compounds 1 is efficiently achieved, within 3 to 15 minutes under microwave irradiation by a solvent free reaction in the presence of carefully adjusted amounts of piperidine leading to Knocvenagel products 3 in good to excellent yields.
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Doi:10.1021/ja01262a066
(1942)Doi:10.1016/S0040-4020(01)82840-4
(1969)Doi:10.1016/S0022-1139(02)00126-4
(2002)Doi:10.1021/ja01163a057
(1950)Doi:10.1021/ja047436p
(2004)Doi:10.1016/j.carres.2013.12.020
(2014)
