Synthesis of novel 4-(5'-pyrrolidinyl)-β-lactams

Article abstract of DOI:10.1016/S0040-4020(99)00867-4

The synthesis of novel 4-(5'-pyrrolidinyl)-β-lactams from imines derived from 4-formyl-β-lactams and α-amino esters via cascade imine → azomethine ylide → 1,3-dipolar cycloaddition reactions is described. These cascades are endo-specific, exhibit facial stereoselectivity and occur in good to excellent yields.