Bioorganic and Medicinal Chemistry Letters p. 3143 - 3146 (1999)
Update date:2022-07-29
Topics:
Haubmann, Christian
Huebner, Harald
Gmeiner, Peter
Piperidinylpyrroles of type 3 were synthesized through a modified Paal-Knorr reaction. For the introduction of pyrrole-substituents high yielding transformations including Sonogashira cross-coupling reactions were utilized. Employment of the reagent TosMIC gave access to the regioisomeric oxazolyl derivatives 7 and 11 which showed the highest dopamine D4 receptor binding of the series investigated.
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