Bioorganic and Medicinal Chemistry Letters p. 3175 - 3180 (1999)
Update date:2022-08-02
Topics:
De Jonghe, Steven
Van Overmeire, Ilse
Poulton, Samantha
Hendrix, Chris
Busson, Roger
Van Calenbergh, Serge
De Keukeleire, Denis
Spiegel, Sarah
Herdewijn, Piet
Short-chain sphinganine analogues 8, 9, 18, and 19, as well as 3-fluoro-sphingosine analogues 25 and 26 were synthesized. Their potential as sphingosine kinase inhibitors was investigated, in combination with previously synthesized sphingosine and fluorin
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