Bioorganic and Medicinal Chemistry Letters p. 2685 - 2691 (2004)
Update date:2022-07-30
Topics:
Linton, Steven D.
Aja, Teresa
Allegrini, Peter R.
Deckwerth, Thomas L.
Diaz, Jose-Luis
Hengerer, Bastian
Herrmann, Julia
Jahangiri, Kathy G.
Kallen, Joerg
Karanewsky, Donald S.
Meduna, Steven P.
Nalley, Kip
Robinson, Edward D.
Roggo, Silvio
Rovelli, Giorgio
Sauter, Andre
Sayers, Robert O.
Schmitz, Albert
Smidt, Robert
Ternansky, Robert J.
Tomaselli, Kevin J.
Ullman, Brett R.
Wiessner, Christoph
Wu, Joe C.
Structural modifications were made to a previously described acyl dipeptide caspase inhibitor, leading to the oxamyl dipeptide series. Subsequent SAR studies directed toward the warhead, P2, and P4 regions of this novel peptidomimetic are described herein.
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(2004)