Origin of the slow-binding inhibition of aldolase by D-glycero-tetrulose 1-phosphate (D-erythrulose 1-phosphate) from the comparison with the isosteric phosphonate analog

Article abstract of DOI:10.1002/(sici)1099-0690(199911)1999:11<2853::aid-ejoc2853>3.0.co;2-0

The mechanistic reaction pathway for the slow-binding inhibition of rabbit muscle aldolase by D-glycero-tetrulose 1-phosphate (D-erythrulose 1- phosphate) was investigated through the use of its phosphonomethyl isoster 4 which was synthezised for this stu