Synthesis of 4-(2-diphenylphosphino-1-naphthyl)-2-phenylquinazoline; A potential P-N chelating ligand for asymmetric catalysis

Article abstract of DOI:10.1016/S0040-4039(99)01648-2

We describe a multistep synthesis leading in a good yield to the title compound. The biaryl linkage was formed in a Pd-catalysed coupling of 2-phenyl-4-chloroquinazoline with 2-methoxy-1-naphthylboronic acid. A further metal-catalysed reaction gave the formation of the naphthylphosphorus bond allowing us to obtain the required phosphonimine ligand 1 as the racemate.