
Bioorganic and Medicinal Chemistry Letters p. 3439 - 3440 (1999)
Update date:2022-08-04
Topics:
Cossy, Janine
Menciu, Cecilia
Rakotoarisoa, Haja
Kahn, Philippe H.
Desmurs, Jean-Roger
Troglitazone was obtained in 5 steps from 4-bromo-1,1-dimethoxy-3-methylbut-2-ene with an overall yield of 7.5%. The formation of the chromane ring was achieved by condensing an unsaturated acetal with trimethylhydroquinone in the presence of bis(trifluoromethylsulfonyl)imide.
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