A radical cyclization strategy for the concise total synthesis of (±)-geissoschizine

Article abstract of DOI:10.1016/S0040-4039(97)01186-6

A short synthetic route to (±)-geissoschizine (1) was developed that features the construction of a Corynanthe-skeleton via radical cyclization of vinyl iodide, which was easily prepared by assembly of three fragments. New pentacyclic molecules formed by the radical cyclization were also reported.