Synthesis of the cyclic heptapeptide Substance P antagonist, dihydro-WIN67689 and determination of the stereochemistry of the modified tyrosine moiety

DOI: 10.1016/S0040-4039(99)01930-9

Source and publish data:

Tetrahedron Letters p. 9097 - 9100 (1999)

Update date:2022-08-05

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Authors:

Li, Yuan-Qiang

Sugase, Kenji

Ishiguro, Masaji

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Article abstract of DOI:10.1016/S0040-4039(99)01930-9

The total synthesis of semi-synthetic cyclic heptapeptide dihydro-WIN67689, a Substance P antagonist 70 times more potent than the naturally occurring cyclic peptide WIN66306, established the stereochemistry of the β-OH group in the isoprenyltyrosine moiety in I-III as R.

Full text of DOI:10.1016/S0040-4039(99)01930-9

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