Solution phase combinatorial chemistry using cyclotriveratrylene-based tripodal scaffolds

Article abstract of DOI:10.1016/S0040-4039(99)01979-6

A library consisting of 40 cyclotriveratrylene-based tripodal scaffold molecules was constructed by O-alkylation of the CTV-triol followed by coupling of one or two amino acids; apart from the wash steps in the work-up the reaction products did not require additional purification. Preliminary screening experiments revealed that a dansylated receptor molecule selectively bound N-acylated dipeptides.