Journal of labelled compounds and radiopharmaceuticals p. 65 - 75 (2000)
Update date:2022-07-30
Topics:
Goodwin, Thomas E.
Zhou, Xiang
Haile, Pamela A.
Breen, Phil
Anderson, Paula J.
Hiller, F. Charles
Compadre, Cesar M.
A convenient synthesis of an isotopically-labelled version (13C,2H3) of the longacting β2-adrenergic agonist, salmeterol, is described, starting from methyl salicylate, 1,6-dibromohexane and 4-phenyl-1-butanol. This compound was designed as an analytical internal standard for mass spectrometric determination of salmeterol in pharmacokinetic studies.
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