Synthesis of 13C,2H3-salmeterol: An analytical internal standard for pharmacokinetic studies

DOI: 10.1002/(SICI)1099-1344(200001)43:1<65::AID-JLCR291>3.0.CO;2-2

Source and publish data:

Journal of labelled compounds and radiopharmaceuticals p. 65 - 75 (2000)

Update date:2022-07-30

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Authors:

Goodwin, Thomas E.

Zhou, Xiang

Haile, Pamela A.

Breen, Phil

Anderson, Paula J.

Hiller, F. Charles

Compadre, Cesar M.

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Article abstract of DOI:10.1002/(SICI)1099-1344(200001)43:1<65::AID-JLCR291>3.0.CO;2-2

A convenient synthesis of an isotopically-labelled version (¹³C,²H₃) of the longacting β₂-adrenergic agonist, salmeterol, is described, starting from methyl salicylate, 1,6-dibromohexane and 4-phenyl-1-butanol. This compound was designed as an analytical internal standard for mass spectrometric determination of salmeterol in pharmacokinetic studies.

Full text of DOI:10.1002/(SICI)1099-1344(200001)43:1<65::AID-JLCR291>3.0.CO;2-2

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