Development of plasmin-selective inhibitors and studies of their structure-activity relationship

DOI: 10.1248/cpb.48.184

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 184 - 193 (2000)

Update date:2022-09-26

Topics:

Authors:

Okada, Yoshio

Matsumoto, Yoshikazu

Tsuda, Yuko

Tada, Mayako

Wanaka, Keiko

Hijikata-Okunomiya, Akiko

Okamoto, Shosuke

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1248/cpb.48.184

Various compounds were synthesized by combining three components at positions P₁, P₁, and P₂,. Of these, N-(trans-4- aminomethylcyclohexanecarbonyl)-Tyr(O-2-bromobenzyloxycarbonyl)-octylamide inhibited plasmin selectively with IC₅₀ values of 0.80 and 0.23 μM towards S-2251 and fibrin, respectively. This compound also inhibited plasma kallikrein, urokinase, thrombin and trypsin with IC₅₀ values of 10, >50, >50 and 1.6 μM, respectively.

Full text of DOI:10.1248/cpb.48.184

NII-Electronic Library Service

Products guided by the article

Product name:carbonic acid 2-bromo-benzyl ester 4-(2-tert-butoxycarbonylamino-3-isobutoxycarbonyloxy-3-oxo-propyl)-phenyl ester

Cas No:263272-44-2

R&D Labs maybe for 263272-44-2

Shanghai Sunwise Chemical Co., Ltd

website:http://www.sunwisechem.com

Contact:86-021-33883180

Address:Room 10E, Building G, Westlink Center, No. 2337 Gudai Road, Minhang District, Shanghai, China PC: 201100
Beijing Zhongshuo Pharmaceutical T & D Co.,Ltd

Contact:0086-10-64430626

Address:ea No 16, HEPINGLI,DONGCHENG DISTRICT,BEIJING,P.R.CHINA.
Compro Shijiazhuang Fine Chemical Co., Ltd

Contact:0086-311-89689838

Address:Economic and Technological Development Zone of Shijiazhuang,Hebei
Cartoon Ingredients Co., Ltd

website:http://www.cartoonchem.com/

Contact:+86-25-58074918

Address:Room 2109, RuiHua Business Center,315 South ZhongShan Road, Nanjing 210001, China
Zhejiang Kaili Industrial Co., Ltd

Contact:+86-571-85241926

Address:lantian business center,No.18 Moganshan Road

Relevant to this article

Doi:10.1021/ja01349a029
(1932)
An efficient and convenient synthesis of 5-formylsalicylaldehyde

Doi:10.1080/00397910008087117
(2000)
Doi:10.1021/jo00803a026
(1971)
Batch and in-flow kinetic resolution of racemic 1-(N-acylamino)alkylphosphonic and 1-(N-acylamino)alkylphosphinic acids and their esters using immobilized penicillin G acylase

Doi:10.1016/j.tetasy.2016.11.007
(2017)
Coordination chemistry and catalytic activity of ruthenium(II) complexes containing a phospha-macrocyclic ligand

Doi:10.1016/j.poly.2012.06.079
(2013)
Nickel complexes with two types of noninnocent ligands: α-Diimine and phenazine

Doi:10.1021/om400130m
(2013)

Article Doi