Chemical and Pharmaceutical Bulletin p. 184 - 193 (2000)
Update date:2022-09-26
Topics:
Okada, Yoshio
Matsumoto, Yoshikazu
Tsuda, Yuko
Tada, Mayako
Wanaka, Keiko
Hijikata-Okunomiya, Akiko
Okamoto, Shosuke
Various compounds were synthesized by combining three components at positions P1, P1, and P2,. Of these, N-(trans-4- aminomethylcyclohexanecarbonyl)-Tyr(O-2-bromobenzyloxycarbonyl)-octylamide inhibited plasmin selectively with IC50 values of 0.80 and 0.23 μM towards S-2251 and fibrin, respectively. This compound also inhibited plasma kallikrein, urokinase, thrombin and trypsin with IC50 values of 10, >50, >50 and 1.6 μM, respectively.
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