The Journal of Organic Chemistry
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Myoglobin-Catalyzed Intermolecular Carbene N-H Insertion with
Author Contributions
Arylamine Substrates. Chem. Commun. 2015, 51, 1532-1534.
(5) Tyagi, V.; Bonn, R. B.; Fasan, R. Intermolecular Carbene S-H
Insertion Catalysed by Engineered Myoglobin-Based Catalysts.
Chem. Sci. 2015, 6, 2488-2494.
(6) Kan, S. B. J.; Lewis, R. D.; Chen, K.; Arnold, F. H. Directed
Evolution of Cytochrome C for Carbon-Silicon Bond Formation:
Bringing Silicon to Life. Science 2016, 354, 1048-1051.
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‡ E.J.M. and V.S. contributed equally to this work.
Notes
The authors declare no competing financial interest.
ACKNOWLEDGMENT
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Engineering of Rumb: Toward a Green Catalyst for Carbene
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K.; Meichin, H.; Zhao, L. M.; Wolf, M. W.; Nakayama, A.; Hasegawa,
J.; Lehnert, N.; Hayashi, T. Catalytic Cyclopropanation by
Myoglobin Reconstituted with Iron Porphycene: Acceleration of
Catalysis Due to Rapid Formation of the Carbene Species. J. Am.
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This work was supported by the U.S. National Institute of
Health (NIH) grant GM098628. E.J.M. acknowledges support
from the NIH Graduate Training Grant T32GM118283. MS
instrumentation was supported by the U.S. NSF grant CHE-
0946653. The authors are grateful to Dr. Jermaine Jenkins and
the Structure Biology & Biophysics Facility at the University of
Rochester for providing access to the CD instrumentation.
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