Stereocontrolled synthesis of substituted tetrahydropyrans from 1,3-dioxan-4-ones

Article abstract of DOI:10.1016/0040-4039(95)02114-0

Conversion of aldehydes to 1,3-dioxan-4-ones, followed by methylenation with dimethyl titanocene gave the corresponding vinyl acetals which could undergo a stereocontrolled aluminum-mediated rearrangement to afford substituted tetrahydropyrans.