Syntheses of L-glutamic acid analogues for neuroexcitatory activity studies

Article abstract of DOI:10.1002/jccs.200000010

Starting from D-serine, (2S,3S)-, (2S,3R)-substituted-L-glutamic acids were prepared via Claisen rearrangement methodology. A variety of the substituents can be introduced at the C-3 of the L-glutamic acid backbone.