A facile synthesis of substituted phenylglycines

Article abstract of DOI:10.1080/00397910008087127

A convenient scaleable process for the preparation of substituted phenylglycines 2 by a modified Strecker reaction is described. Bisulfite- mediated addition of benzylamine and cyanide anion to substituted benzaldehydes 3 gave the aminonitriles 4 which were hydrolysed in two steps to the N-protected amino acid 1. Debenzylation using catalytic transfer hydrogenation gave the title compounds in good yield.

Full text of DOI:10.1080/00397910008087127

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Synthetic Communications: An
International Journal for Rapid
Communication of Synthetic
Organic Chemistry
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A Facile Synthesis of
Substituted Phenylglycines
Antony J. Davies a , Michael S. Ashwood a & Ian F.
Cottrell a
a Merck Sharp and Dohme Research Laboratories,
Department of Process Research , Hertford Road,
Hoddesdon, Hertfordshire, EN11 9BU, England Fax:
E-mail:
Published online: 04 Dec 2007.
To cite this article: Antony J. Davies , Michael S. Ashwood & Ian F. Cottrell (2000)
A Facile Synthesis of Substituted Phenylglycines, Synthetic Communications: An
International Journal for Rapid Communication of Synthetic Organic Chemistry, 30:6,
1095-1102, DOI: 10.1080/00397910008087127
To link to this article: http://dx.doi.org/10.1080/00397910008087127
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