A novel synthesis of a 2,8-dioxabicyclo[3.2.1]octane skeleton from a 2,5-dialkyltetrahydrofuran derivative

Article abstract of DOI:10.3987/com-99-s148

A unique method for the construction of 6,7-dihydroxy-2,8- dioxabicyclo[3.2.1]octane, a core component of zaragogic acids, was developed based on zinc acetate-mediated rearrangement reaction of a 2,5- dialkyltetrahydrofuran derivative having a 1'-monochlate on the C2-side chain.