Effect of polymethylene and phenylene linking groups on the DNA cleavage specificity of distamycin-linked hydroxamic acid-vanadyl complexes

DOI: 10.1248/cpb.48.603

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 603 - 609 (2000)

Update date:2022-08-05

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Authors:

Hashimoto, Shigeki

Inui, Takahiro

Nakamura, Yushin

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Article abstract of DOI:10.1248/cpb.48.603

Two types of distamycin-linked hydroxamic acids (DHA), which contain various lengths of polymethylene chains (PM-DHA) and relatively rigid phenylene ones (Ph-DHA), have been synthesized for the first time. Their DNA cleavage specificities were investigate

Full text of DOI:10.1248/cpb.48.603

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