Synthesis of Cyanosubstituted Di- and Tetrahydropyridines in DIMCARB (Dimethylamine-CO2-Adduct)

DOI: 10.1002/prac.19973390173

Source and publish data:

Advanced Synthesis and Catalysis p. 414 - 419 (1997)

Update date:2022-08-03

Topics:

Authors:

Dunkel Dunkel

Hess Hess

Reck Reck

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1002/prac.19973390173

A new selective method for base-catalyzed ring closure reaction of acetophenones (1a-1) with malononitrile in DIMCARB (dimethylamine-CO₂-addition-compound) as solvent of high dimethy lamine concentration is reported, which allows effective syntheses of (1.2-dihydro-4-pyrid-6-yl)dicyanomethanides and 5-cyano-6-dicyanomethylene-1,2,3,6-tetrahydropyridines in good yields. The structure of the two new classes of compounds is proved by X-ray diffraction analysis.

Full text of DOI:10.1002/prac.19973390173

Products guided by the article

Product name:Propanedinitrile, [1-(2-nitrophenyl)ethylidene]-

Cas No:28448-10-4

R&D Labs maybe for 28448-10-4

Zhengzhou Institute of Chiral Pharmer Research Co., Ltd.

Contact:86-371-55219111

Address:15 Floor, 2 Building, Central China Technovalley, Zhongyuan West Road
Refine Chemicals Science & Technology Technology Developing Co., Ltd.

Contact:+86-22-87899130

Address:No.12,west keyan road,Tianjin City
Hubei Onward Bio-Development Co., Ltd.

Contact:+86-718-8417012

Address:No.517,Shizhou Avenue,Enshi City,Hubei Province,China,445002
Jiangsu Taihu New Materials Holding Co., Ltd

Contact:+86-519-86160108

Address:Xueyan Town, Changzhou City, Jiangsu Province, 213169, China
PINGYUAN SIHUAN PHARMACEUTICAL CO., LTD

Contact:+86-531-55696072

Address:#2766,yinxiu Road, Economic Development Zone, Pingyuan Country, Shandong Province, China.

Relevant to this article

Doi:10.1016/S0040-4039(01)88694-9
(1969)
A zinc - Aldimine complex

Doi:10.1016/S0020-1693(99)00535-6
(2000)
Design, synthesis and biological screening of 2-aminobenzamides as selective HDAC3 inhibitors with promising anticancer effects

Doi:10.1016/j.ejps.2018.08.030
(2018)
Metal complexes of 2-aza-2-benzyl-5,10,15,20-tetraphenyl-21-carbaporphyrin: M(2-NCH₂C₆H₅NCTPP) (M = Ni²⁺, Pd²⁺) and Mn(2-NCH₂C₆H₅NCTPP)Br (NCTPP = N-confused 5,10,15,20-tetraphenyl porphyrinate)

Doi:10.1016/j.poly.2011.09.034
(2012)
Heme Oxygenase Inhibition by α-(1H-Imidazol-1-yl)-ω-phenylalkanes: Effect of Introduction of Heteroatoms in the Alkyl Linker

Doi:10.1002/cmdc.201100602
(2012)
Comparison of symmetric and asymmetric bipolar type high triplet energy host materials for deep blue phosphorescent organic light-emitting diodes

Doi:10.1039/c2jm30742a
(2012)

Article Doi