Synthesis of Cyanosubstituted Di- and Tetrahydropyridines in DIMCARB (Dimethylamine-CO2-Adduct)

DOI: 10.1002/prac.19973390173

Source and publish data:

Advanced Synthesis and Catalysis p. 414 - 419 (1997)

Update date:2022-08-03

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Authors:

Dunkel Dunkel

Hess Hess

Reck Reck

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Article abstract of DOI:10.1002/prac.19973390173

A new selective method for base-catalyzed ring closure reaction of acetophenones (1a-1) with malononitrile in DIMCARB (dimethylamine-CO₂-addition-compound) as solvent of high dimethy lamine concentration is reported, which allows effective syntheses of (1.2-dihydro-4-pyrid-6-yl)dicyanomethanides and 5-cyano-6-dicyanomethylene-1,2,3,6-tetrahydropyridines in good yields. The structure of the two new classes of compounds is proved by X-ray diffraction analysis.

Full text of DOI:10.1002/prac.19973390173

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