Chemical modification of the α-mannosidase inhibitor mannostain A: Synthesis of a potent inhibitor 1L-(1,2,3,5/4)-5-amino-4-O-methyl-1,2,3,4- cyclopentanetetrol

Article abstract of DOI:10.1002/ejoc.200500118

Demethylthio-, S-demethyl-, and S-ethyl derivatives of the α-mannosidase inhibitor, mannostasin A, were synthesized and evaluated for their inhibition of Jack bean α-mannosidase with the prime objective of elucidating the role of the methylthio group. All