New nonsteroidal steroid 5α-reductase inhibitors. Syntheses and structure-activity studies on carboxamide phenylalkyl-substituted pyridones and piperidones

DOI: 10.1002/(SICI)1521-4184(20005)333:5<145::AID-ARDP145>3.0.CO;2-Q

Source and publish data:

Archiv der Pharmazie p. 145 - 153 (2000)

Update date:2022-09-26

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Authors:

Hartmann, Rolf W.

Reichert, Martin

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Article abstract of DOI:10.1002/(SICI)1521-4184(20005)333:5<145::AID-ARDP145>3.0.CO;2-Q

In the search for nonsteroidal inhibitors of 5α-reductase for the treatment of benign prostatic hyperplasia (BPH), we synthesized diisopropyl (1a-8a) and tert-butyl (1b-8b) benzamides, as well as ethyl benzoates (1c, 3c), which were substituted in 4 posit

Full text of DOI:10.1002/(SICI)1521-4184(20005)333:5<145::AID-ARDP145>3.0.CO;2-Q

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