Synthesis of diaryl-substituted imidazo[1,2-a]pyridines designed as potential aromatase inhibitors

DOI: 10.1248/cpb.48.935

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 935 - 940 (2000)

Update date:2022-09-26

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Authors:

Enguehard, Cecile

Renou, Jean-Louis

Allouchi, Hassan

Leger, Jean-Michel

Gueiffier, Alain

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Article abstract of DOI:10.1248/cpb.48.935

From a pharmacophore model of bicyclic heterocycles as aromatase inhibitors we have designed three series of imidazo[1,2-a]pyridine derivatives. The synthesis and the spectroscopy determination of various compounds are reported. The crystal data of one of these compounds (10b) was obtained. The aromatase inhibition potency was evaluated in vitro and no activity was found.

Full text of DOI:10.1248/cpb.48.935

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