Chemical and Pharmaceutical Bulletin p. 935 - 940 (2000)
Update date:2022-09-26
Topics:
Enguehard, Cecile
Renou, Jean-Louis
Allouchi, Hassan
Leger, Jean-Michel
Gueiffier, Alain
From a pharmacophore model of bicyclic heterocycles as aromatase inhibitors we have designed three series of imidazo[1,2-a]pyridine derivatives. The synthesis and the spectroscopy determination of various compounds are reported. The crystal data of one of these compounds (10b) was obtained. The aromatase inhibition potency was evaluated in vitro and no activity was found.
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