Preparation of N,N-bis[2-[N',N'-bis[(tert-butoxycarbonyl)methyl]-amino]ethyl-L-aspartic acid: An intermediate in the synthesis of MRI contrast agents

Article abstract of DOI:10.1080/00397910008087003

A preparation of DTPA carboxylic acid 1, a suitable intermediate in the synthesis of MRI contrast agents 2, is described starting from α-tert-butyl-β-benzyl-L-aspartate hydrochloride. In addition, an alternative procedure for the synthesis of bromide 3b is presented.

Full text of DOI:10.1080/00397910008087003

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Synthetic Communications: An
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Preparation of N,N-
Bis[2-[N',N'-Bis[(Tert-
Butoxycarbonyl)Methyl]-
Amino]Ethyl-L-Aspartic
Acid: An Intermediate in the
Synthesis of MRI Contrast
Agents
J. C. Amedio Jr. a , G. Van Wagenen Jr a , G. Zavlin a
, Albert Gyorkos b & S. A. Peterson b
a Chemical Development , EPIX Medical, Inc. , 71
Rogers St., Cambridge, MA, 02142--1118, USA
b Hauser Laboratories , 5555 Airport Blvd, Boulder,
CO, 80301--2339, USA
Published online: 04 Dec 2007.
To cite this article: J. C. Amedio Jr. , G. Van Wagenen Jr , G. Zavlin , Albert
Gyorkos & S. A. Peterson (2000) Preparation of N,N-Bis[2-[N',N'-Bis[(Tert-
Butoxycarbonyl)Methyl]-Amino]Ethyl-L-Aspartic Acid: An Intermediate in the Synthesis
of MRI Contrast Agents, Synthetic Communications: An International Journal for
Rapid Communication of Synthetic Organic Chemistry, 30:20, 3755-3763, DOI:
10.1080/00397910008087003
To link to this article: http://dx.doi.org/10.1080/00397910008087003

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