C-P bond-forming reactions via C-O/P-h cross-coupling catalyzed by nickel

Article abstract of DOI:10.1021/ja512498u

The first Ni-catalyzed C-O/P-H cross-coupling producing organophosphorus compounds is disclosed. This method features wide generality in regard to both C-O and P-H compounds: for C-O compounds, the readily available alcohol derivatives of aryl, alkenyl, benzyl, and allyl are applicable, and for P-H compounds, both >P^V(O)H compounds (secondary phosphine oxide, H-phosphinate, and H-phosphonate) and hydrogen phosphines (>P^IIIH) can be used as the substrates. Thus, a variety of valuable C(sp²)-P and C(sp³)-P compounds can be readily obtained in good to excellent yields by this new strategy.