Synthesis and pharmacological properties of N-thienyl alkylenediamines

Article abstract of DOI:10.1016/0223-5234(88)90099-2

A series of N-thienylalkylenediamines was synthesized and tested for their analgesic, anti-inflammatory and anti-pyretic activities, as well as for their acute toxicity and central effects.Acetylsalicylic acid, phenylbutazone and indomethacin were used as reference drugs.Several compounds showed interesting aspirin-like properties associated with good systemic and gastric tolerance.Keywords: 2-nitrothiophenes / N-thienyl alkylenediamines / anti-inflammatory activity / analgesic activity / basic anti-inflammatory agents