European Journal of Medicinal Chemistry p. 553 - 560 (1988)
Update date:2022-08-05
Topics:
Ronsisvalle, Giuseppe
Pappalardo, Maria S.
Vittorio, Franco
Pasquinucci, Lorella
Caruso, Antonina
et al.
A series of N-thienylalkylenediamines was synthesized and tested for their analgesic, anti-inflammatory and anti-pyretic activities, as well as for their acute toxicity and central effects.Acetylsalicylic acid, phenylbutazone and indomethacin were used as reference drugs.Several compounds showed interesting aspirin-like properties associated with good systemic and gastric tolerance.Keywords: 2-nitrothiophenes / N-thienyl alkylenediamines / anti-inflammatory activity / analgesic activity / basic anti-inflammatory agents
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