Acylation of α-fluorophosphonoacetate derivatives using magnesium chloride-triethylamine

Article abstract of DOI:10.1016/S0040-4020(99)00807-8

Acylation of α-fluorophosphonoacetate derivatives in the presence of magnesium chloride-triethylamine has been described. Acylations of triethyl α-fluorophosphonoacetate 1 and diethyl α-fluorophosphonoacetic acid 7 were proceeded under mild conditions to provide α-fluoro-β-keto esters 3 and α- fluoro-β-keto phosphonates 9, respectively, in high yields.