A practical synthesis of the ABC ring model of ecteinascidins

DOI: 10.1248/cpb.48.1549

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1549 - 1557 (2000)

Update date:2022-08-04

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Authors:

Saito Saito

Tachi Tachi

Seki Seki

Kamayachi

Kubo Kubo

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Article abstract of DOI:10.1248/cpb.48.1549

A practical synthesis of 1,2,3,4,5,6-hexahydro-1,5-imino-10-hydroxy-9-methoxy-3,8,11-trimethyl-3-benza zocin-4-one (3) as an ABC ring model compound of ecteinascidin 743 and safracins from 3-hydroxy-4-methoxy-5-methylbenzaldehyde (7) is described. The overall yield in 15 step is 27%.

Full text of DOI:10.1248/cpb.48.1549

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