Bioorganic and Medicinal Chemistry p. 49 - 64 (1997)
Update date:2022-09-26
Topics:
Gallagher, Timothy F.
Seibel, George L.
Kassis, Shouki
Laydon, Jeffrey T.
Blumenthal, Mary Jane
Lee, John C.
Lee, Dennis
Boehm, Jeffrey C.
Fier-Thompson, Susan M.
Abt, Jeffrey W.
Soreson, Margaret E.
Smietana, Juanita M.
Hall, Ralph F.
Garigipati, Ravi S.
Bender, Paul E.
Erhard, Karl F.
Krog, Arnold J.
Hofmann, Glenn A.
Sheldrake, Peter L.
McDonnell, Peter C.
Kumar, Sanjay
Young, Peter R.
Adams, Jerry L.
Members of three classes of pyridinylimidazoles bind with varying affinities to CSBP (p38) kinase which is a member of a stress-induced signal transduction pathway. Based upon SAR and protein homology modeling, the pharmacophore and three potential modes of binding to the enzyme are presented. For a subset of pyridinylimidazoles, binding is shown to correlate with inhibition of CSBP kinase activity, whereas no significant inhibition of PKA, PKα and ERK kinase activity is observed.
View MoreJinTan Pingsheng Chemical Co.,Ltd
Contact:+86-519-82828200
Address:NO.11Danfengxilu Road,Jintan City,Jiangsu,China
shanghai Tauto Biotech Co., Ltd
website:http://www.tautobiotech.com/en/index.htm
Contact:+86-21-51320588 ext. 8025
Address:No. 326, Aidisheng Rd , Zhangjiang Hi-tech Park, Shanghai , P.R.CHINA
Shanghai Balmxy Pharmaceutical Co., Ltd
Contact:0086-21-24206007
Address:Room 402, 15#, No. 909 wangyue Road, shanghai, P. R. China
Shifang Taifeng New Flame Retardant Co., Ltd
Contact:02884721008
Address:tingjiang industrial park, hefeng town
Hangzhou GreenCo Science & Technology Co., Ltd.
Contact:86-571-88257303
Address:1713 Room,Jingui Building,Gudun Road,Xihu District,Hangzhou,China
Doi:10.1021/acs.jmedchem.0c02266
(2021)Doi:10.1021/jo01292a012
(1980)Doi:10.1016/j.bioorg.2009.10.001
(2010)Doi:10.1016/j.ejmech.2011.08.014
(2011)Doi:10.1155/2019/2467970
(2019)Doi:10.1016/S0040-4020(02)01184-5
(2002)
