1562
E.A. Romero-Sandoval et al
Antinociception induced by NCX-701
CHAPMAN, V. & DICKENSON, A.H. (1992). The combination of
NMDA antagonism and morphine produces profound antinoci-
ception in the rat dorsal horn. Brain Res., 573, 321 ± 323.
DAVIES, S.N. & LODGE, D. (1987). Evidence for the involvement of
N-methylaspartate receptors in `wind-up' of class 2 neurones in
the dorsal horn of the rat. Brain Res., 424, 402 ± 406.
KEEFER, L.K., NIMS, R.W., DAVIES, K.M. & WINK, D.A. (1996).
``NONOates'' (1-substituted diazen-1-ium-1,2.diolates) as nitric
oxide donors: convenient nitric oxide dosage forms. Methods
Enzymol., 268, 281 ± 293.
KISS, J.P. & VIZI, E.S. (2001). Nitric oxide: a novel link between
synaptic and nonsynaptic transmission. TiNS, 24, 211 ± 215.
DE FELIPE, C., HERRERO, J.F., O'BRIENY, J.A. PALMERY, J.A.,
DOYLEY, C.A., SMITH, A.J.H., LAIRD, J.M.A., BELMONTE, C.,
CERVERO, F. & HUNT, S.P. (1998). Altered nociception, analgesia
and aggression in the mice lacking the substance P receptor.
Nature, 392, 394 ± 397.
KURIHARA, T. & YOSHIOKA, K. (1996). The excitatory and
inhibitory modulation of primary aerent ®bre-evoked responses
of ventral roots in the neonatal rat spinal cord exerted by nitric
oxide. Br. J. Pharmacol., 118, 1743 ± 1753.
MAZARIO, J. & HERRERO, J.F. (1999). Antinociceptive eects of
metamizol (dipyrone) in rat single motor units. Neurosci. Lett.,
273, 1 ± 14.
MAZARIO, J., GAITAN, G. & HERRERO, J.F. (2001). Cyclooxygenase-
1 vs cyclooxigenase-2 inhibitors in the induction of antinocicep-
tion in rodent withdrawal re¯exes. Neuropharmacology, 40, 937 ±
945.
NISHIHARA, I., MINAMI, T., WATANABE, Y., ITO, S. & HAYAISHI, O.
(1995). Prostaglandin E2 stimulates glutamate release from
synaptosomes of rat spinal cord. Neurosci. Lett., 196, 57 ± 60.
OCHS, H.R., GREENBLATT, D.J., ABERNETHY, D.R., ARENDT, R.M.,
GERLOFF, J., EICHELKRAUT, W. & HAHN, N. (1985). Cere-
brospinal ¯uid uptake and peripheral distribution of centrally
acting drugs: relation to lipid solubility. J. Pharm. Pharmacol.,
37, 428 ± 431.
DEL SOLDATO, P., SORRENTINO, R.
& PINTO, A. (1999). NO-
aspirins: a class of new anti-in¯ammatory and antithrombotic
agents. TiPS, 20, 319 ± 323.
DICKENSON, A.H. & SULLIVAN, A.F. (1987). Evidence for a role of
the NMDA receptor in the frequency dependent potentiation of
deep rat dorsal horn nociceptive neurones following C ®bre
stimulation. Neuropharmacology, 26, 1235 ± 1238.
FIORUCCI, S. (2001). NO-releasing NSAIDs are caspase inhibitors.
Trends in Immunology, 22, 232 ± 235.
FUTTER, L.E., AL-SWAYEH, O.A. & MOORE, P.K. (2001). A
comparison of the eect of nitroparacetamol and paracetamol
on liver injury. Br. J. Pharmacol., 132, 10 ± 12.
& HERRERO, J.F. (2002). Subeective doses of
GAITAN, G.
dexketoprofen trometamol enhance the potency and duration
of fentanyl antinociception. Br. J. Pharmacol., (in press).
HERRERO, J. F. & CERVERO, F. (1996a). Changes in nociceptive
re¯ex facilitation during carrageenan-induced arthritis. Brain
Res., 717, 62 ± 68.
PELISSIER, T., ALLOUI, A., PAEILE, C. & ESCHALIER, A. (1995).
Evidence for a central antinociceptive eect of paracetamol
involving spinal 5HT3 receptors. Neuroreport, 6, 1546 ± 1548.
PINI, L.A., VITALE, G., OTTANI, A.
& SANDRINI, M. (1997).
HERRERO, J. F. & CERVERO, F. (1996b). Supraspinal in¯uences on
the facilitation of rat nociceptive re¯exes induced by carrageenan
monoarthritis. Neurosci Lett., 209, 21 ± 24.
HERRERO, J.F. & HEADLEY, P.M. (1991). The eects of sham and
full spinalization on the systemic potency of m- and k-opioids on
spinal nociceptive re¯exes in rats. Br. J. Pharmacol., 104, 166 ±
170.
HERRERO, J.F. & HEADLEY, P.M. (1996). Reversal by naloxone of
the spinal antinociceptive actions of a systemically administered
NSAID. Br. J. Pharmacol., 118, 968 ± 972.
Naloxone-reversible antinociception by paracetamol in the rat.
J. Pharmacol. Exp. Ther., 280, 934 ± 940.
ROMERO-SANDOVAL, A., MAZARIO, J. & HERRERO, J.F. (2001).
Comparison of the analgesic eects of paracetamol and NO-
paracetamol in rat single motor units. In¯amm. Res., 50, S211.
SOLANO, R.E. & HERRERO, J.F. (1997). Cutaneous responsiveness of
rat single motor units activated by natural stimulation. J.
Neurosci. Methods, 73, 135 ± 140.
SOUSA, A.M. & PRADO, W.A. (2001). The dual eect of a nitric oxide
donor in nociception. Brain Res., 897, 9 ± 19.
HERRERO, J.F., LAIRD, J.M.A. & LOPEZ-GARCIA, J.A. (2000). Wind-
up of spinal cord neurones and pain sensation: much ado about
something? Prog. Neurobiol., 61, 169 ± 203.
HERRERO, J.F., THORN, S.A. & HEADLEY, P.M. (1996). Relative
peripheral, spinal and supraspinal actions of a non-steroidal anti-
in¯ammatory drug (¯unixin) compared to a mu-opioid agonist
(fentanyl) on nociceptive re¯exes in the rat. Analgesia, 2, 11 ± 18.
HRABIE, J.A., KLOSE, J.R., WINK, D.A. & KEEFER, L.K. (1993). New
nitric oxide-releasing zwitterions derived from polyamines. J.
Org. Chem., 58, 1472 ± 1476.
THORN, S.A., HERRERO, J.F. & HEADLEY, P.M. (1994). Stimulus
intensity and the comparative ecacy of m- and k-opioid agonists
on nociceptive spinal re¯exes in the rat. Brain Res., 663, 352 ±
356.
WALLACE, J.L., DEL SOLDATO, P., CIRINO, G. & MUSCARA, M.N.
(1999). Nitric oxide-releasing NSAIDs: GI-safe antithrombotics.
Idrugs, 2, 321 ± 326.
(Received December 11, 2001
Revised December 27, 2001
Accepted January 4, 2002)
British Journal of Pharmacology vol 135 (6)