Synthesis of Oligoinosinates with 2'-5' Internucleotide Linkage in Aqueous Solution Using Pb2+ Ion

Article abstract of DOI:10.1246/bcsj.54.2759

Oligoinosinates up to a pentamer were synthesized by the polymerization of inosine-5'-phosphorimidazolide in aqueous solution using Pb²⁺ ion. 2'-5' Internucleotide linkage was preferentially formed.The yields of the 2'-5' linked dimer, trimer, and tetramer were 14.8, 4.5, and 1.6percent, respectively.A small amount of linkage isomers of oligoinosinates with 3'-5' linkage was obtained.The products were characterized by sequential enzyme tests.