A sequential electrochemical oxidation - Olefin metathesis strategy for the construction of bicyclic lactam based peptidomimetics

Article abstract of DOI:10.1016/S0040-4039(98)00858-2

A sequential electrochemical amide oxidation - ring closing olefin metathesis sequence has been used to overcome problems associated with the synthesis of seven-membered ring lactam containing bicyclic peptidomimetics. The synthesis of several previously unavailable bicyelic lactam building blocks for constructing constrained thyroliberin analogs is described.