Synthesis of a tripeptide derivative containing the Phe-Arg hydroxyethylene dipeptide isostere.

Article abstract of DOI:10.1021/ol015612i

The protected hydroxyethylene dipeptide isostere of Phe-Arg and the tripeptide derivative 1 were synthesized as components of potential peptidase inhibitors. Key to the success of these syntheses is selective rhodium-catalyzed hydroboration in the presenc