Synthesis of some new thieno[2,3-b]pyridines, pyrido[3′,2′:4,5]-thieno[3,2-d]pyrimidines and pyrido[3′,2′:4,5]thieno[3,2-d][1,2,3]-triazines

Article abstract of DOI:10.1080/10426500008076538

4-Aryl-3-cyano-2-substituted-methylthiocyclopenta[b]pyridines (3a-c and 4a-i) were prepared by reaction of 4-aryl-3-cyanocyclopenta[b]pyridine-2(1H)-thiones(2a-c) with chloroacetonitrile or chloro-N-arylacelamides, respectively. On treatment of these products with sodium ethoxide in boiling ethanol, they underwent intramolecular Thorpe-Ziegler cyclization to afford the corresponding 3-amino-4-aryl-2-functionallized-cyclopenta[e]thieno [2,3-b]pyridines (5a-c and 6a-i). Most of the latter thienopyridines were used as synthons for the target cyclopenta[5′,6′]pyrido[3′,2′:4,5]thieno[3,2-d] pyrimidines and cyclopenta[5′,6′] pyrido[3′,2′:4,5]thieno[3,2-d)[1,2,3]triazines.

Full text of DOI:10.1080/10426500008076538

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Phosphorus, Sulfur, and
Silicon and the Related
Elements
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SYNTHESIS OF SOME NEW
THIENO[2,3-b]PYRIDINES,
PYRIDO[3′,2′:4,5]-
THIENO[3,2-
d]PYRIMIDINES AND
PYRIDO[3′,2′:4,5]THIENO[3,2-
d][1,2,3]-TRIAZINES
A. E. Abdel-rahman a , E. A. Bakhite a , O. S.
Mohamed a & E. A. Thabet a
a Chemistry Department, Faculty of science ,
Assiut University , Assiut, 71516, Egypt
Published online: 19 Dec 2006.
To cite this article: A. E. Abdel-rahman , E. A. Bakhite , O. S. Mohamed
& E. A. Thabet (2000) SYNTHESIS OF SOME NEW THIENO[2,3-b]PYRIDINES,
PYRIDO[3′,2′:4,5]-THIENO[3,2-d]PYRIMIDINES AND PYRIDO[3′,2′:4,5]THIENO[3,2-
d][1,2,3]-TRIAZINES, Phosphorus, Sulfur, and Silicon and the Related Elements,
166:1, 149-171, DOI: 10.1080/10426500008076538
To link to this article: http://dx.doi.org/10.1080/10426500008076538
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