Journal of Medicinal Chemistry p. 5912 - 5922 (2004)
Update date:2022-08-03
Topics:
Hopkins, Andrew L.
Ren, Jingshan
Milton, John
Hazen, Richard J.
Chan, Joseph H.
Stuart, David I.
Stammers, David K.
We have used a structure-based approach to design a novel series of non-nucleoside inhibitors of HIV-1 RT (NNRTIs). Detailed analysis of a wide range of crystal structures of HIV-1 RT-NNRTI complexes together with data on drug resistance mutations has ide
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