Selective Reduction of Pyridazin-3-ones and Ring Contraction to Pyrrolidin-2-ones and 3-Pyrrolin-2-ones

DOI: 10.1039/c39840001373

Source and publish data:

Journal of the Chemical Society. Chemical communications p. 1373 - 1374 (1984)

Update date:2022-08-04

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Authors:

Brown, George R.

Foubister, Alan J.

Wright, Brian

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Article abstract of DOI:10.1039/c39840001373

Reduction of pyridazin-3-ones (1a-d) with zinc dust in acetic acid affords selectively 4,5-dihydropyridazin-3-ones (2a-d), but N(2)-substituted (1) react further with excess of zinc to give equal amounts of pyrrolidin-2-ones (3) and 3-pyrrolin-2-ones (4).

Full text of DOI:10.1039/c39840001373

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