European Journal of Medicinal Chemistry p. 422 - 431 (2013)
Update date:2022-08-04
Topics:
Sashidhara, Koneni V.
Palnati, Gopala Reddy
Sonkar, Ravi
Avula, Srinivasa Rao
Awasthi, Chetan
Bhatia, Gitika
In our continuing search for safe and efficacious antidyslipidemic agents, structurally interesting coumarin-chalcone fibrates were synthesized and evaluated in triton WR-1339 induced hyperlipidemic rats. The most active compound 41 decreased the total cholesterol (TC), phospholipids (PL) and triglycerides (TG), of hyperlipidemic rats by 26, 24, and 25% respectively. In addition, the compound 41 significantly reversed the levels of VLDL, LDL HDL and also increased the LPL activity. Altogether, our data suggests that these novel hybrids would be a potential new class of therapeutic agents against dyslipidemia.
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(1970)Doi:10.1021/jm00300a046
(1970)Doi:10.1021/ol034319a
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