Organic Letters p. 3793 - 3796 (2002)
Update date:2022-08-05
Topics:
Bream, Robert N.
Ley, Steven V.
Procopiou, Panayiotis A.
(Matrix Presented) The enantioselective synthesis of (R)-salmeterol has been achieved by using a sequence of supported reagents and sequestering agents. The saligenin core was installed by a regiospecific alkylation and a chiral auxiliary approach was employed to introduce the desired stereochemistry via a diastereoselective reduction.
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(1945)