Desymmetrisation of meso propargylic diols

Article abstract of DOI:10.1016/S0040-4039(00)60642-1

Meso acetylenic diols, conveniently separated from their threo isomers via the corresponding adducts with bromine, have been converted into optically pure derivatives by either lipase-catalysed hydrolysis of the corresponding diacetates or ketalisation of (+)-menthone.