Synthesis of sp3-rich chemical libraries based upon 1,2-diazetidines

DOI: 10.1016/j.tet.2020.131836

Source and publish data:

Tetrahedron (2021)

Update date:2022-08-03

Topics:

Authors:

Dean, Conor

Roesner, Stefan

Rajkumar, Sundaram

Clarkson, Guy J.

Jones, Matthew

Shipman, Michael

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Article abstract of DOI:10.1016/j.tet.2020.131836

A strategy for the creation of sp³-rich, non-planar scaffolds for drug discovery is described. Stereocontrolled ring opening of homochiral 1,2-epoxides by hydrazine monohydrate followed by selective protection of both nitrogen atoms and Mitsuno

Full text of DOI:10.1016/j.tet.2020.131836

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